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Acute Premyelocytic Leukemia

APL (or M3 type) accounts 10% of all acute myeloid leukemia and is the most dangerous one. Usually, APL is treated by chemotherapy and radiotherapy. Unfortunately, many patients treated with these methods relapse and become drug tolerant, thus being more difficult to treat. Even worse, the most powerful therapy, myeloid transplant, cannot be widely applied due to the many restrictions of itself.

Arsenious acid injection, which we have successfully used in dealing with APL for a long time, is a Chinese medicine. Its low ratio of relapse and long remission duration makes it very welcome in most APL patients of China and has intrigued many medicine professionals of other countries.

Arsenious Acid Injection has got patent of China and has been certified as prescription drug by National Drug Administration, China. The application for international patent and FDA certification are under progress.

The side effects were few and minor, according to the pilot study done at Memorial Sloan-Kettering Cancer Center in New York City and published in New England Journal of Medicine.

Commodity NameArsenious acid injection
DescriptionColorless, transparent liquid
Main IngredientsArsenic trioxide (As2O3)
Function MechanismInduce modulation and degradation of PML-RAR alpha proteins resulting the normal differentiation and pass-away of leukemia cells.
Therapeutic RangeAcute premyelocytic leukemia (APL, or M3 type)
Administration & Dosage5-10mg/day (5% glucose or 0.9%Nacl 500ml, intravenous drip), 4-6 weeks/course
Comments
  1. It has no cross-resistance with ATRA, so being especially useful to relapsed cases.
  2. This drug has toxicity; please use it under the guidance of your doctor.
  3. It is not indicated for use during pregnancy or with liver/kidney dysfunction.
  4. When side effects (liver/kidney impairment, nausea, dyspepsia, flatulence) occur, discontinue and until the symptoms are controlled.
  5. In the emergent cases of over dosage, BAL can rescue.
Clinical Results
  1. On our cases of 244, 126 live above 5 years, 19 live above 10 years.
  2. In more than 60 cases of Rui Jin Hospital, Shanghai, China, 91% got CR (complete remission)
PriceRMB5125/kit (10mg*5) US$657Buy now!

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