Acute Premyelocytic Leukemia
(or M3 type) accounts 10% of all acute myeloid leukemia and is the most dangerous
one. Usually, APL is treated by chemotherapy and radiotherapy. Unfortunately,
many patients treated with these methods relapse and become drug tolerant, thus
being more difficult to treat. Even worse, the most powerful therapy, myeloid
transplant, cannot be widely applied due to the many restrictions of itself.
acid injection, which we have successfully used in dealing with APL for a long
time, is a Chinese medicine. Its low ratio of relapse and long remission duration
makes it very welcome in most APL patients of China and has intrigued many medicine
professionals of other countries.
Acid Injection has got patent of China and has been certified as prescription
drug by National Drug Administration, China. The application for international
patent and FDA certification are under progress.
side effects were few and minor, according to the pilot study done at Memorial
Sloan-Kettering Cancer Center in New York City and published in New England Journal
Mechanism||Induce modulation and
degradation of PML-RAR alpha proteins resulting the normal differentiation and
pass-away of leukemia cells.|
Range||Acute premyelocytic leukemia
(APL, or M3 type)|
& Dosage||5-10mg/day (5% glucose or 0.9%Nacl
500ml, intravenous drip), 4-6 weeks/course|
- It has no cross-resistance with ATRA, so being especially
useful to relapsed cases.
- This drug has toxicity; please use
it under the guidance of your doctor.
- It is not indicated
for use during pregnancy or with liver/kidney dysfunction.
side effects (liver/kidney impairment, nausea, dyspepsia, flatulence) occur, discontinue
and until the symptoms are controlled.
- In the emergent cases
of over dosage, BAL can rescue.
On our cases of 244, 126 live above 5 years, 19 live above 10 years.
more than 60 cases of Rui Jin Hospital, Shanghai, China, 91% got CR (complete
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