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Life Extension of Canelim Capsules on H22 tumor-bearing mice

Yuan B. Xiang et al., Xian Medical University

Result (3 tests):

 

Cases
Dosage
Body weight
Survival days
Life extension
(mg/kg)
before

after

(d)
rate(%)
Test 1
Normal control
10
--
18.9 1.3
26.1 2.9
>40
H22 control
10
--
19.0 1.2
30.4 3.8
8.9 2.0
Canelim
11
100
19.3 1.1
34.1 6.3
11.0 1.8
23.6
12
200
19.2 1.0
27.7 5.1
13.7 6.7*
53.9
12
400
19.2 1.3
34.9 7.8
17.0 7.8**
91.0
Test 2
Normal control
10
--
19.2 1.3
27.2 2.6
>40
H22 control
10
--
18.5 0.9
32.5 3.3
9.0 1.5
Canelim
10
100
19.1 1.0
32.1 6.0
10.5 1.6
16.7
10
200
18.5 0.7
34.1 6.5
11.4 1.3*
26.7
10
400
19.6 0.7
32.7 7.0
12.2 2.7*
35.6
Test 3
Normal control
10
--
18.6 0.8
25.0 1.2
>40
H22 control
10
--
19.6 0.7
33.1 2.3
8.5 1.6
Canelim
11
100
18.5 0.7
34.7 2.9
11.0 7.5
29.4
12
200
18.2 0.4
35.5 4.5
11.7 2.3*
37.6

 

10
400
18.2 0.4
31.5 6.2
12.4 0.5*
45.9

compared with H22 tumor control group, * means p<0.05, ** means p<0.01

Discuss:

The life exttension rate differs with the dosage of Canelim Capsules. When compared with H22 tumor control group, the difference is significant in the middle and large dosage group (p<0.05, p<0.01). With the large doseage(0.4 g/kg), the survival rate extended attains to 36% to 91% respectively.

Conclusion

Canelim Capsules can inhibit the tumor and significantly extend survival period of H22 tumor- bearing mice.

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