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Immune enhancement of Canelim Capsules on S180 tumor-bearing mice

Yuan B. Xiang et al., Xian Medical University

Result:

Group
Cases
Dosage
Phagocytose Rate
Spleen index
Lymphocyt proliferation
(/kg)
(%)
rate(%)
Normal Control
10
20ml
35.2 7.9
8.76 1.05**
49.9 5.7**
S180 Control
10
20ml
30.2 7.7
6.93 1.26
36.7 3.2
Canelim
10
0.1g
36.4 9.3
8.81 1.49*
39.2 4.0
10
0.2g
40.0 8.1*
7.76 1.05
43.7 1.8**
10
0.4g
39.6 6.7*
7.52 1.39
43.8 2.9**
Cy
10
5mg
10.6 3.4**
5.16 1.25**
17.1 2.1**
10
20mg
8.24 2.60**
4.83 1.41**
15.8 0.9**
Canelim + Cy
10
0.1+5
18.2 5.9**++
7.12 1.82++
39.3 3.1++

compared with S180 tumor control group, * means p<0.05, ** means p<0.01
compared with cyclophosphamide 5 mg group, + means p<0.05, ++ means p<0.01

Discuss:

a.Canelim Capsules (0.2-0.4 g/kg) can boost the phagocytic function of phagocytes in abdominal cavity of mice. On the contrary, Cyclophosphamide inhibits it. When combined, Canelim Capsules can partially reverse this inhibition effect.
b.Low dosage of Canelim Capsules(0.1 g/kg) can increase the spleen index. But this function is not apparent in middle and large dosage. Cyclophosphamide, in dosage of 5, 20mg/kg, decrease spleen index. When combined, Canelim Capsules can completely reverse this inbition effect.
c. Middle and large dosage of Canelim Capsules (0.2, 0.4g/kg) can increase splenic lymphocyt proliferation rate. On the contrary, Cyclophosphamide can obviously inhibit it. The inbibition rate arrives 53.4% and 56.9%. When combined, Canelim Capsules can completely reverse this inhibition effect.

Conclusion:

Canelim Capsules can boost both specific and non-specific cellular & humoral immunity. It can also reverse the immunity inhibition caused by chemotherapy.

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