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Tumor inhibition of Canelim Capsules on S180 tumor-bearing mice

Yuan B. Xiang et al., Xian Medical University

Result (3 tests):

Group

Cases
Dosage
Body Weight (g)
Tumor weight
Inhibition Rate
n
(mg/kg)
before treatment
after treatment
(g)
(%)
Test 1
Normal Control
10
--
20.1 1.1
24.2 1.9**
S180 Control
10
--
19.1 1.2
30.9 3.2

4.25 1.00

Canelim
10
100
19.1 1.3
29.0 3.4
0.64 0.31**
84.9
10
200
18.9 0.9
29.7 6.8
0.49 0.17**
88.5
10
400
18.1 0.3
28.1 3.7**
0.36 0.18**
91.5
Test 2
Normal Control
10
--
19.9 2.0
27.1 2.7**
S180 Control
10
--
20.6 2.2
30.1 1.6
2.76 1.10
Canelim
10
100
20.1 2.0
31.1 2.0
1.64 0.75**
35.1
10
200
20.1 1.3
30.7 3.0
1.78 0.38**
35.5
10
400
1.86 1.3
26.3 3.5**
1.79 0.59**
40.6
Test 3
Normal Control
10
--
18.7 0.9
26.4 2.4
S180 Control
10
--
18.2 0.4
28.7 7.5
2.26 0.67
Canelim
10
100
20.0 1.3
26.1 3.2
0.74 0.44**
59.3
10
200
20.9 1.4
26.3 4.1
0.79 0.34**
65.0
10
400
19.5 1.5
23.1 3.8*
0.86 0.41**
67.3

compared with S180 tumor control group, * means p<0.05, ** means p<0.01

Discuss:

a. Tumor weight decreased greatly after the administration of Canelim Capsules (0.1-0.4 g/kg), compared with the tumor control group, the difference is significant. The inhibition rate is between 35% and 85%
b. The weight of S180 tumor-bearing mice decreased slightly, but it remains in the normal range.

Conclusion

Canelim Capsules can significantly kill S180 tumor cells and shrink, inhibit it from further development.


 

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